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Androgenic repression of hexobarbitone metabolism and action in Crl:CD-1 (ICR)BR mice.

Mice of the Crl:CD-1 (ICR)BR strain exhibit a sexual dimorphism in hexobarbitone metabolism and action. Compared to females, males have a lower Vmax and a higher Km for hepatic microsomal hexobarbitone hydroxylase. In agreement with the enzyme studies, hexobarbitone-induced sleeping times were great...

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Main Authors: Shapiro, B. H., Szczotka, S. M.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 1984
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1986963/
https://ncbi.nlm.nih.gov/pubmed/6704585
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