A role for histone deacetylase activity in HDAC1-mediated transcriptional repression

Treatment of mammalian cells with small molecule histone deacetylase (HDAC) inhibitors induces changes in the transcription of specific genes. These changes correlate directly with an increase in the acetylation levels of all four core histones in vivo. Antibodies directed against endogenous HDAC1,...

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Main Authors: Hassig, Christian A., Tong, Jeffrey K., Fleischer, Tracey C., Owa, Takashi, Grable, Phyllis G., Ayer, Donald E., Schreiber, Stuart L.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 1998
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC19868/
https://ncbi.nlm.nih.gov/pubmed/9520398
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