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Histidine-rich glycoprotein inhibits the antiangiogenic effect of thrombospondin-1

Angiogenesis is critical for the growth and proliferation of tumors as well as for normal development. We now describe a novel role for histidine-rich glycoprotein (HRGP) in the modulation of angiogenesis. HRGP is a plasma protein that circulates in relatively high concentrations (1.5 μM), but has n...

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Détails bibliographiques
Auteurs principaux: Simantov, Ronit, Febbraio, Maria, Crombie, René, Asch, Adam S., Nachman, Ralph L., Silverstein, Roy L.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2001
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC198540/
https://ncbi.nlm.nih.gov/pubmed/11134179
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