Histidine-rich glycoprotein inhibits the antiangiogenic effect of thrombospondin-1

Angiogenesis is critical for the growth and proliferation of tumors as well as for normal development. We now describe a novel role for histidine-rich glycoprotein (HRGP) in the modulation of angiogenesis. HRGP is a plasma protein that circulates in relatively high concentrations (1.5 μM), but has n...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Simantov, Ronit, Febbraio, Maria, Crombie, René, Asch, Adam S., Nachman, Ralph L., Silverstein, Roy L.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 2001
Schlagworte:	Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC198540/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11134179/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI9061
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