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Allergen-induced bronchial hyperreactivity and eosinophilic inflammation occur in the absence of IgE in a mouse model of asthma

In patients with asthma, elevations of IgE correlate both with allergic inflammation of the airways and with bronchial hyperreactivity (BHR). Several investigations, using mouse models of this disease, have indicated a central role for IgE in the pathogenesis of the eosinophilic inflammation as well...

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Detalhes bibliográficos
Main Authors: Mehlhop, Paul D., van de Rijn, Matthijs, Goldberg, Alison B., Brewer, Joanne P., Kurup, Viswanath P., Martin, Thomas R., Oettgen, Hans C.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences of the USA 1997
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC19793/
https://ncbi.nlm.nih.gov/pubmed/9037055
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