Targeting thyroid hormone receptor-β agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index

Despite efforts spanning four decades, the therapeutic potential of thyroid hormone receptor (TR) agonists as lipid-lowering and anti-obesity agents remains largely unexplored in humans because of dose-limiting cardiac effects and effects on the thyroid hormone axis (THA), muscle metabolism, and bon...

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Detalhes bibliográficos
Main Authors: Erion, Mark D., Cable, Edward E., Ito, Bruce R., Jiang, Hongjian, Fujitaki, James M., Finn, Patricia D., Zhang, Bao-Hong, Hou, Jinzhao, Boyer, Serge H., van Poelje, Paul D., Linemeyer, David L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1978486/
https://ncbi.nlm.nih.gov/pubmed/17878314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702759104
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