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Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging

Targeted delivery represents a promising approach for the development of safer and more effective therapeutics for oncology applications. Although macromolecules accumulate nonspecifically in tumors through the enhanced permeability and retention (EPR) effect, previous studies using nanoparticles to...

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Detalles Bibliográficos
Autores principales: Bartlett, Derek W., Su, Helen, Hildebrandt, Isabel J., Weber, Wolfgang A., Davis, Mark E.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2007
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1978218/
https://ncbi.nlm.nih.gov/pubmed/17875985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707461104
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