Doxorubicin selected multidrug-resistant small cell lung cancer cell lines characterised by elevated cytoplasmic Ca2+ and resistance modulation by verapamil in absence of P-glycoprotein overexpression.

Sublines from the small cell lung cancer (SCLC) cell lines U1285 and U1690, denoted U1285-100, U1285-250, U1690-40 and U1690-150, were adapted to grow in the continuous presence of 100, 250, 40 and 150 ng ml-1 doxorubicin (Dox), respectively. The Dox resistance was accompanied by cross-resistance to...

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Bibliographic Details
Main Authors: Nygren, P., Larsson, R., Gruber, A., Peterson, C., Bergh, J.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 1991
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1977853/
https://ncbi.nlm.nih.gov/pubmed/1684906
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