Modulation of vinblastine sensitivity by dipyridamole in multidrug resistant fibrosarcoma cells lacking mdr1 expression.

We examined the ability of dipyridamole (DPM) to act synergistically with vinblastine (VBL) in HT1080 fibrosarcoma cells and a drug-resistant variant, HT1080/DR4, which lacks mdr1 expression, in order to determine whether DPM requires P-glycoprotein to modulate drug sensitivity. Median effect analys...

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Bibliographische Detailangaben
Hauptverfasser: Shalinsky, D. R., Slovak, M. L., Howell, S. B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 1991
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1977708/
https://ncbi.nlm.nih.gov/pubmed/1680368
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