Modulation of vinblastine sensitivity by dipyridamole in multidrug resistant fibrosarcoma cells lacking mdr1 expression.

We examined the ability of dipyridamole (DPM) to act synergistically with vinblastine (VBL) in HT1080 fibrosarcoma cells and a drug-resistant variant, HT1080/DR4, which lacks mdr1 expression, in order to determine whether DPM requires P-glycoprotein to modulate drug sensitivity. Median effect analys...

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Autors principals: Shalinsky, D. R., Slovak, M. L., Howell, S. B.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 1991
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1977708/
https://ncbi.nlm.nih.gov/pubmed/1680368
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