The effect of ricin B chain on the intracellular trafficking of an A chain immunotoxin.

Covalent linkage of the A chain of ricin to the LICR-LOND-Fib75 monoclonal antibody produced an immunotoxin, Fib75-SS-ricin A, which demonstrated immunospecific toxicity to human bladder carcinoma cells in tissue culture (Forrester et al., 1984). The present studies have shown that ricin B chain pot...

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Autores principales: Timar, J., McIntosh, D. P., Henry, R., Cumber, A. J., Parnell, G. D., Davies, A. J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 1991
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1977687/
https://ncbi.nlm.nih.gov/pubmed/1911213
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