Oestrogen receptor status and the response of human breast cancer cell lines to a combination of methotrexate and 17-beta oestradiol.

We have investigated the modifying influence of 17-beta oestradiol (E2), on the cytotoxicity of methotrexate (MTX) towards two cell lines derived from human breast carcinoma. E2 (10(-7) M-10(-6) M) significantly reduced the antimetabolic effects of the drug towards an E2 non-responsive cell line, MD...

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Bibliographic Details
Main Authors: Clarke, R., Van den Berg, H. W., Kennedy, D. G., Murphy, R. F.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 1985
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1976963/
https://ncbi.nlm.nih.gov/pubmed/3970812
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