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An S/MAR-based infectious episomal genomic DNA expression vector provides long-term regulated functional complementation of LDLR deficiency

Episomal gene expression vectors offer a safe and attractive alternative to integrating vectors. Here we describe the development of a high capacity episomal vector system exploiting human episomal retention sequences to provide efficient vector maintenance and regulated gene expression through the...

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Hlavní autoři: Lufino, Michele M.P., Manservigi, Roberto, Wade-Martins, Richard
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2007
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1976449/
https://ncbi.nlm.nih.gov/pubmed/17675302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm570
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