Susceptibility to type 1 diabetes conferred by the PTPN22 C1858T polymorphism in the Spanish population

BACKGROUND: The protein tyrosine phosphatase N22 gene (PTPN22) encodes a lymphoid-specific phosphatase (LYP) which is an important downregulator of T cell activation. A PTPN22 polymorphism, C1858T, was found associated with type 1 diabetes (T1D) in different Caucasian populations. In this study, we...

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Main Authors: Santiago, Jose Luis, Martínez, Alfonso, de la Calle, Hermenegildo, Fernández-Arquero, Miguel, Figueredo, M Ángeles, de la Concha, Emilio G, Urcelay, Elena
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2007
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1976418/
https://ncbi.nlm.nih.gov/pubmed/17697317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2350-8-54
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