High-throughput Detection of Human Papillomavirus-18 L1 Gene Methylation, a Candidate Biomarker for the Progression of Cervical Neoplasia

The L1 gene of human papillomavirus-18 (HPV-18) is consistently hypermethylated in cervical carcinomas, but frequently hypo- or unmethylated in exfoliated cells from asymptomatic patients. In precancerous lesions, L1 is sporadically hypermethylated, correlating with the severity of the neoplasia. In...

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Main Authors: Turan, Tolga, Kalantari, Mina, Cuschieri, Kate, Cubie, Heather A., Skomedal, Hanne, Bernard., Hans-Ulrich
Format: Artigo
Sprog:Inglês
Udgivet: 2006
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1975683/
https://ncbi.nlm.nih.gov/pubmed/17175003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2006.11.010
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