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Cyclosporin A Elicits Dose-Dependent Biphasic Effects on Osteoblast Differentiation and Bone Formation
Cyclosporin A (CsA) is thought to prevent immune reactions after organ transplantation by inhibiting calcineurin (Cn) and its substrate, the Nuclear Factor of Activated T cells (NFAT). A dichotomy exists in describing the effects of CsA on bone formation. The concept that the suppression of Cn/NFAT...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1974856/ https://ncbi.nlm.nih.gov/pubmed/17392048 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2007.02.017 |
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