Intrathecal administration of 131I radiolabelled monoclonal antibody as a treatment for neoplastic meningitis.

Fifteen patients with neoplastic meningitis received a single intrathecal injection of between 11 and 60 mCi of a 131I radiolabelled monoclonal antibody (MoAb), chosen for its immunoreactivity to tumour. Major toxicity was manifest as nausea, vomiting and headache (7/15 patients), reversible bone ma...

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Main Authors: Moseley, R. P., Davies, A. G., Richardson, R. B., Zalutsky, M., Carrell, S., Fabre, J., Slack, N., Bullimore, J., Pizer, B., Papanastassiou, V.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1990
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1971477/
https://ncbi.nlm.nih.gov/pubmed/2223581
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