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Synergism between 5-fluorouracil and N-methylformamide in HT29 human colon cancer line.

In HT29 cells 5-fluorouracil (5FU) cytotoxicity is enhanced by subsequent incubation of cells in medium containing 1% N-methylformamide (NMF). This enhancement does not appear to be related to differences in the repair of 5FU-induced DNA damage. It is proposed that the inhibition of DNA synthesis by...

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Autori principali: Laudonio, N., Zupi, G., Erba, E., Leonetti, C., D'Incalci, M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 1990
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1971307/
https://ncbi.nlm.nih.gov/pubmed/2328201
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