The 1993 Walter Hubert Lecture: the role of the p53 tumour-suppressor gene in tumorigenesis.

The p53 tumour-suppressor gene is mutated in 60% of human tumours, and the product of the gene acts as a suppressor of cell division. It is thought that the growth-suppressive effects of p53 are mediated through the transcriptional transactivation activity of the protein. Overexpression of the p53 p...

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Bibliographic Details
Main Authors: Levine, A. J., Perry, M. E., Chang, A., Silver, A., Dittmer, D., Wu, M., Welsh, D.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 1994
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1968876/
https://ncbi.nlm.nih.gov/pubmed/8123467
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