Altered stability of etoposide-induced topoisomerase II-DNA complexes in resistant human leukaemia K562 cells.

K562 leukaemia cells were selected for resistance using 0.5 microM etoposide (VP-16). Cloned K/VP.5 cells were 30-fold resistant to growth inhibition by VP-16 and 5- to 13-fold resistant to m-AMSA, adriamycin and mitoxantrone. K/VP.5 cells did not overexpress P-glycoprotein; VP-16 accumulation was s...

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Main Authors: Ritke, M. K., Roberts, D., Allan, W. P., Raymond, J., Bergoltz, V. V., Yalowich, J. C.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1968798/
https://ncbi.nlm.nih.gov/pubmed/8142256
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