The selection of antibodies for targeted therapy of small-cell lung cancer (SCLC) using a human tumour spheroid model to compare the uptake of cluster 1 and cluster w4 antibodies.

Spheroids of a small-cell lung cancer (SCLC) cell line POC were used to evaluate the uptake and penetration of two antibodies recognising different SCLC antigens. Spheroids approximately 300-400 microns in diameter were incubated with 1 microgram ml-1 125I-labelled NY.3D11, an antibody which reacts...

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Detalhes bibliográficos
Main Authors: Olabiran, Y., Ledermann, J. A., Marston, N. J., Boxer, G. M., Hicks, R., Souhami, R. L., Spiro, S. G., Stahel, R. A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1968697/
https://ncbi.nlm.nih.gov/pubmed/8297722
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