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Molecular mechanisms of SR 4233-induced hepatocyte toxicity under aerobic versus hypoxic conditions.

SR 4233 (3-amino-1,2,4-benzotriazine-1,4-dioxide) is the lead compound of the benzotriazene-di-N oxides which are selectively toxic to tumour cells under hypoxic conditions. However much higher concentrations given to rats caused bone marrow toxicity and necrosis of the low oxygen Zone 3 part of the...

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Bibliografski detalji
Glavni autori: Silva, J. M., O'Brien, P. J.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 1993
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1968404/
https://ncbi.nlm.nih.gov/pubmed/8394729
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