Dosage and cycle effects of dacarbazine (DTIC) and fotemustine on O6-alkylguanine-DNA alkyltransferase in human peripheral blood mononuclear cells.

There is increasing experimental evidence to suggest that endogenous expression of O6-alkylguanine-DNA-alkyltransferase (ATase) is a major factor in cellular resistance to certain chemotherapeutic agents including dacarbazine (DTIC). We have recently shown wide interindividual variation in the deple...

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Главные авторы: Lee, S. M., Thatcher, N., Dougal, M., Margison, G. P.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 1993
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1968172/
https://ncbi.nlm.nih.gov/pubmed/8431354
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