Oral piritrexim, an effective treatment for metastatic urothelial cancer.

Piritrexim is a lipid-soluble inhibitor of dihydrofolate reductase (DHFR) that enters tumour cells rapidly by passive diffusion, cannot be polyglutamated, and is as effective as methotrexate in inhibiting DHFR. Bioavailability after oral dosing is approximately 75%. We performed a phase II study wit...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: de Wit, R., Kaye, S. B., Roberts, J. T., Stoter, G., Scott, J., Verweij, J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 1993
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1968166/
https://ncbi.nlm.nih.gov/pubmed/8431372
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