Functional activation of p53 via phosphorylation following DNA damage by UV but not γ radiation
The tumor suppressor p53 is a nuclear phosphoprotein in which DNA-binding activity is increased on exposure to DNA-damaging agents such as UV or γ radiation by unknown mechanisms. Because phosphorylation of p53 at the casein kinase (CK) II site activates p53 for DNA-binding function in vitro, we sou...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19655/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9501176/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.6.2834 |
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