Relationship between Membrane Physical Properties and Secretory Phospholipase A2 Hydrolysis Kinetics in S49 Cells during Ionophore-Induced Apoptosis

During apoptosis, changes occur in lymphocyte membranes that render them susceptible to hydrolysis by secretory phospholipase A(2) (sPLA(2)). To study the relevant mechanisms, a simplified model of apoptosis using a calcium ionophore was applied. Kinetic and flow cytometry experiments provided key o...

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Detalhes bibliográficos
Main Authors: Bailey, Rachel W., Olson, Erin D., Vu, Mai P., Brueseke, Taylor J., Robertson, Leslie, Christensen, Ryan E., Parker, Kristen H., Judd, Allan M., Bell, John D.
Formato: Artigo
Idioma:Inglês
Publicado em: Biophysical Society 2007
Assuntos:
Membranes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1965435/
https://ncbi.nlm.nih.gov/pubmed/17545239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.104679
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