Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans

Here, we report generation and characterization of Disrupted-In-Schizophrenia-1 (DISC1) genetically engineered mice as a potential model for major mental illnesses, such as schizophrenia. DISC1 is a promising genetic risk factor for major mental illnesses. In this transgenic model, a dominant-negati...

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Bibliografische gegevens
Hoofdauteurs: Hikida, Takatoshi, Jaaro-Peled, Hanna, Seshadri, Saurav, Oishi, Kenichi, Hookway, Caroline, Kong, Stephanie, Wu, Di, Xue, Rong, Andradé, Manuella, Tankou, Stephanie, Mori, Susumu, Gallagher, Michela, Ishizuka, Koko, Pletnikov, Mikhail, Kida, Satoshi, Sawa, Akira
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2007
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1964873/
https://ncbi.nlm.nih.gov/pubmed/17675407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0704774104
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