Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration

Autophagy is a regulated lysosomal degradation process that involves autophagosome formation and transport. Although recent evidence indicates that basal levels of autophagy protect against neurodegeneration, the exact mechanism whereby this occurs is not known. By using conditional knockout mutant...

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Библиографические подробности
Главные авторы: Komatsu, Masaaki, Wang, Qing Jun, Holstein, Gay R., Friedrich, Victor L., Iwata, Jun-ichi, Kominami, Eiki, Chait, Brian T., Tanaka, Keiji, Yue, Zhenyu
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2007
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1964831/
https://ncbi.nlm.nih.gov/pubmed/17726112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701311104
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