Gain-of-Function R225W Mutation in Human AMPKγ(3) Causing Increased Glycogen and Decreased Triglyceride in Skeletal Muscle

BACKGROUND: AMP-activated protein kinase (AMPK) is a heterotrimeric enzyme that is evolutionarily conserved from yeast to mammals and functions to maintain cellular and whole body energy homeostasis. Studies in experimental animals demonstrate that activation of AMPK in skeletal muscle protects agai...

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Main Authors: Costford, Sheila R., Kavaslar, Nihan, Ahituv, Nadav, Chaudhry, Shehla N., Schackwitz, Wendy S., Dent, Robert, Pennacchio, Len A., McPherson, Ruth, Harper, Mary-Ellen
Format: Artigo
Language:Inglês
Published: Public Library of Science 2007
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1964808/
https://ncbi.nlm.nih.gov/pubmed/17878938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000903
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