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Type I IFN innate immune response to adenovirus-mediated IFN-γ gene transfer contributes to the regression of cutaneous lymphomas

The fact that adenoviral vectors activate innate immunity and induce type I IFNs has not been fully appreciated in the context of cancer gene therapy. Type I IFNs influence different aspects of human immune response and are believed to be crucial for efficient tumor rejection. We performed transcrip...

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Detalhes bibliográficos
Main Authors: Urosevic, Mirjana, Fujii, Kazuyasu, Calmels, Bastien, Laine, Elisabeth, Kobert, Nikita, Acres, Bruce, Dummer, Reinhard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1964512/
https://ncbi.nlm.nih.gov/pubmed/17823660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32077
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