Canonical Wnt signals are essential for homeostasis of the intestinal epithelium
To assess the critical role of Wnt signals in intestinal crypts, we generated transgenic mice ectopically expressing Dickkopf1 (Dkk1), a secreted Wnt inhibitor. We find that epithelial proliferation is greatly reduced coincidentally with the loss of crypts. Although enterocyte differentiation appear...
Guardat en:
| Publicat a: | Genes Dev |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Cold Spring Harbor Laboratory Press
2003
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC196179/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12865297/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.267103 |
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