Cop9/signalosome subunits and Pcu4 regulate ribonucleotide reductase by both checkpoint-dependent and -independent mechanisms

The signalosome is implicated in regulating cullin-dependent ubiquitin ligases. We find that two signalosome subunits, Csn1 and Csn2, are required to regulate ribonucleotide reductase (RNR) through the degradation of a small protein, Spd1, that acts to anchor the small RNR subunit in the nucleus. Sp...

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Bibliografische gegevens

Gepubliceerd in:	Genes Dev
Hoofdauteurs:	Liu, Cong, Powell, Kelly A., Mundt, Kirsten, Wu, LeJung, Carr, Antony M., Caspari, Thomas
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Cold Spring Harbor Laboratory Press 2003
Onderwerpen:	Research Paper
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC196048/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12695334/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1090803
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