The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity

We show that the Xenopus homologs of Ndc80/Tid3/HEC1 (xNdc80) and Nuf2/MPP1/Him-10 (xNuf2) proteins physically interact in a 190-kD complex that associates with the outer kinetochore from prometaphase through anaphase. Injecting function-blocking antibodies to either xNdc80 or xNuf2 into XTC cells c...

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Detalhes bibliográficos
Main Authors: McCleland, Mark L., Gardner, Richard D., Kallio, Marko J., Daum, John R., Gorbsky, Gary J., Burke, Daniel J., Stukenberg, P. Todd
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2003
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC195965/
https://ncbi.nlm.nih.gov/pubmed/12514103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1040903
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