Histone deacetylase degradation andMEF2 activation promote the formation of slow-twitch myofibers

Skeletal muscle is composed of heterogeneous myofibers with distinctive rates of contraction, metabolic properties, and susceptibility to fatigue. We show that class II histone deacetylase (HDAC) proteins, which function as transcriptional repressors of the myocyte enhancer factor 2 (MEF2) transcrip...

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Bibliografski detalji
Glavni autori: Potthoff, Matthew J., Wu, Hai, Arnold, Michael A., Shelton, John M., Backs, Johannes, McAnally, John, Richardson, James A., Bassel-Duby, Rhonda, Olson, Eric N.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2007
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1957540/
https://ncbi.nlm.nih.gov/pubmed/17786239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31960
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