Histone deacetylase degradation andMEF2 activation promote the formation of slow-twitch myofibers

Skeletal muscle is composed of heterogeneous myofibers with distinctive rates of contraction, metabolic properties, and susceptibility to fatigue. We show that class II histone deacetylase (HDAC) proteins, which function as transcriptional repressors of the myocyte enhancer factor 2 (MEF2) transcrip...

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Hauptverfasser: Potthoff, Matthew J., Wu, Hai, Arnold, Michael A., Shelton, John M., Backs, Johannes, McAnally, John, Richardson, James A., Bassel-Duby, Rhonda, Olson, Eric N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2007
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1957540/
https://ncbi.nlm.nih.gov/pubmed/17786239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31960
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