Interferon-α/β inhibition of interleukin 12 and interferon-γ production in vitro and endogenously during viral infection

Interferon (IFN)-α/β-mediated negative regulation of interleukin 12 (IL-12) and IFN-γ proteins is reported here. Both IFN-α and IFN-β inhibited fixed Staphylococcus aureus Cowan strain induction of IL-12 and IFN-γ production by mouse splenic leukocytes in culture. Extended studies with IFN-α demonst...

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Detalhes bibliográficos
Main Authors: Cousens, Leslie P., Orange, Jordan S., Su, Helen C., Biron, Christine A.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences of the USA 1997
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC19565/
https://ncbi.nlm.nih.gov/pubmed/9012836
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