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Cytochrome c oxidase deficiency in neurons decreases both oxidative stress and amyloid formation in a mouse model of Alzheimer's disease

Defects in the mitochondrial cytochrome c oxidase (COX) have been associated with Alzheimer's Disease, in which the age-dependent accumulation of β-amyloid plays an important role in synaptic dysfunction and neurodegeneration. To test the possibility that age-dependent decline in the mitochondr...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Fukui, Hirokazu, Diaz, Francisca, Garcia, Sofia, Moraes, Carlos T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1955773/
https://ncbi.nlm.nih.gov/pubmed/17715058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705738104
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