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Blinded validation of the isolated arterially perfused rabbit ventricular wedge in preclinical assessment of drug-induced proarrhythmias

BACKGROUND: The development of preclinical models with high predictive value for the identification of drugs with a proclivity to induce Torsade de Pointes (TdP) in the clinic has long been a pressing goal of academia, industry and regulatory agencies alike. The present study provides a blinded appr...

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Hlavní autoři: Liu, Tengxian, Brown, Barry S, Wu, Ying, Antzelevitch, Charles, Kowey, Peter R, Yan, Gan-Xin
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1955432/
https://ncbi.nlm.nih.gov/pubmed/16876745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2006.04.021
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