Bile acids in combination with low pH induce oxidative stress and oxidative DNA damage: relevance to the pathogenesis of Barrett's oesophagus

BACKGROUND: Barrett's oesophagus is a premalignant condition associated with an increased risk for the development of oesophageal adenocarcinoma (ADCA). Previous studies indicated that oxidative damage contributes to the development of ADCA. OBJECTIVE: To test the hypothesis that bile acids and...

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Autors principals: Dvorak, Katerina, Payne, Claire M, Chavarria, Melissa, Ramsey, Lois, Dvorakova, Barbora, Bernstein, Harris, Holubec, Hana, Sampliner, Richard E, Guy, Naihsuan, Condon, Amanda, Bernstein, Carol, Green, Sylvan B, Prasad, Anil, Garewal, Harinder S
Format: Artigo
Idioma:Inglês
Publicat: BMJ Group 2007
Matèries:
Gastro-Oesophageal Reflux
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1954874/
https://ncbi.nlm.nih.gov/pubmed/17145738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2006.103697
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