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Matrix bound SFD mutant TIMP‐3 is more stable than wild type TIMP‐3

BACKGROUND: Sorsby's fundus dystrophy (SFD) is a degenerative retinopathy characterised by accumulation of mutant TIMP‐3 protein in Bruch's membrane. AIM: To compare the stability of matrix bound SFD mutant TIMP‐3s with wild type TIMP‐3. METHODS: COS‐7 cells were transfected with plasmids...

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Detalhes bibliográficos
Main Authors: Majid, Mohammed A, Smith, Valerie A, Newby, Andrew C, Dick, Andrew D
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Group 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1954801/
https://ncbi.nlm.nih.gov/pubmed/17383996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bjo.2006.113225
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