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Inhibition of polyketide synthesis in Alternaria alternata by the fatty acid synthesis inhibitor cerulenin.

The fatty acid synthase inhibitor cerulenin (50 to 100 micrograms/ml) inhibited production of the polyketide mycotoxins alternariol (AOH) and alternariol monomethyl ether (AME) by the mold Alternaria alternata. The results suggested that AOH synthesis was inhibited by a direct mechanism by cerulenin...

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Bibliographic Details
Published in:Appl Environ Microbiol
Main Authors: Hiltunen, M, Söderhäll, K
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1992
Subjects:
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC195377/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1575478/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aem.58.3.1043-1045.1992
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