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ATP-Dependent Chromatin Remodeling Is Required for Base Excision Repair in Conventional but Not in Variant H2A.Bbd Nucleosomes

In eukaryotes, base excision repair (BER) is responsible for the repair of oxidatively generated lesions. The mechanism of BER on naked DNA substrates has been studied in detail, but how it operates on chromatin remains unclear. Here we have studied the mechanism of BER by introducing a single 8-oxo...

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Bibliographic Details
Main Authors: Menoni, Hervé, Gasparutto, Didier, Hamiche, Ali, Cadet, Jean, Dimitrov, Stefan, Bouvet, Philippe, Angelov, Dimitar
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2007
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1952146/
https://ncbi.nlm.nih.gov/pubmed/17591702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00376-07
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