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Reconstruction and Function of Ancestral Center-of-Tree Human Immunodeficiency Virus Type 1 Proteins

The extensive diversity of human immunodeficiency virus type 1 (HIV-1) and its capacity to mutate and escape host immune responses are major challenges for AIDS vaccine development. Ancestral sequences, which minimize the genetic distance to circulating strains, provide an opportunity to design immu...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Rolland, Morgane, Jensen, Mark A., Nickle, David C., Yan, Jian, Learn, Gerald H., Heath, Laura, Weiner, David, Mullins, James I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1951385/
https://ncbi.nlm.nih.gov/pubmed/17537854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02683-06
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