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Adaptation of Borna Disease Virus to New Host Species Attributed to Altered Regulation of Viral Polymerase Activity

Borna disease virus (BDV) can persistently infect the central nervous system of a broad range of mammalian species. Mice are resistant to infections with primary BDV isolates, but certain laboratory strains can be adapted to replicate in mice. We determined the molecular basis of adaptation by study...

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Autores principales: Ackermann, Andreas, Staeheli, Peter, Schneider, Urs
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2007
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1951315/
https://ncbi.nlm.nih.gov/pubmed/17522214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00334-07
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