Protease-Activated Receptor 2 Mediates Human Beta-Defensin 2 and CC Chemokine Ligand 20 mRNA Expression in Response to Proteases Secreted by Porphyromonas gingivalis

The oral pathogen Porphyromonas gingivalis secretes proteases such as Arg-gingipain B (RgpB) that activate protease-activated receptors (PARs). Human beta-defensins (hBDs) and the macrophage inflammatory protein 3α/CC chemokine ligand 20 (CCL20) produced by epithelial cells are antimicrobial peptide...

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Detalhes bibliográficos
Main Authors: Dommisch, Henrik, Chung, Whasun O., Rohani, Maryam G., Williams, David, Rangarajan, Minnie, Curtis, Mike A., Dale, Beverly A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1951157/
https://ncbi.nlm.nih.gov/pubmed/17591792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00455-07
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