Short-term sPECAM-Fc treatment ameliorates EAE while chronic use hastens onset of symptoms

The homotypic cell adhesion molecule PECAM-1 is a major participant in the migration of leukocytes across endothelium. We examined the ability of a chimeric soluble sPECAM-1 fused to human IgG-Fc to impair leukocyte entry through the blood-brain barrier and reduce CNS autoimmunity. sPECAM-Fc impaire...

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Hlavní autoři: Reinke, Emily K., Lee, JangEun, Zozulya, Alla, Karman, Jozsef, Muller, William A., Sandor, Matyas, Fabry, Zsuzsanna
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1950937/
https://ncbi.nlm.nih.gov/pubmed/17467062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2007.03.014
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