Human microRNA-155 on Chromosome 21 Differentially Interacts with Its Polymorphic Target in the AGTR1 3′ Untranslated Region: A Mechanism for Functional Single-Nucleotide Polymorphisms Related to Phenotypes

Animal microRNAs (miRNAs) regulate gene expression through base pairing to their targets within the 3′ untranslated region (UTR) of protein-coding genes. Single-nucleotide polymorphisms (SNPs) located within such target sites can affect miRNA regulation. We mapped annotated SNPs onto a collection of...

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Autori principali: Sethupathy, Praveen , Borel, Christelle , Gagnebin, Maryline , Grant, Gregory R. , Deutsch, Samuel , Elton, Terry S. , Hatzigeorgiou, Artemis G. , Antonarakis, Stylianos E. 
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Human Genetics 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1950808/
https://ncbi.nlm.nih.gov/pubmed/17668390
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