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Epoxygenase Eicosanoids: Synthesis of Tetrahydrofuran-Diol Metabolites and Their Vasoactivity

Eight members of a recently identified family of tetrahydrofuran-diols (THFDs), originating from epoxyeicosatrienoic acids (EETs), were prepared stereospecifically from D-(+)-glucose. The THFDs potently induced relaxation of pre-contracted bovine arteries.

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Bibliographische Detailangaben
Hauptverfasser: Falck, J. R., Reddy, L. Manmohan, Byun, Kihwan, Campbell, William B., Yi, Xiu-Yu
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1950572/
https://ncbi.nlm.nih.gov/pubmed/17293113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.01.096
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