Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk

GTP cyclohydrolase 1 (GCH1) is rate limiting in the provision of the cofactor tetrahydrobiopterin for biosynthesis of catecholamines and NO. We asked whether common genetic variation at GCH1 alters transmitter synthesis and predisposes to disease. Here we undertook a systematic search for polymorphi...

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Main Authors: Zhang, Lian, Rao, Fangwen, Zhang, Kuixing, Khandrika, Srikrishna, Das, Madhusudan, Vaingankar, Sucheta M., Bao, Xuping, Rana, Brinda K., Smith, Douglas W., Wessel, Jennifer, Salem, Rany M., Rodriguez-Flores, Juan L., Mahata, Sushil K., Schork, Nicholas J., Ziegler, Michael G., O’Connor, Daniel T.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2007
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Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1950457/
https://ncbi.nlm.nih.gov/pubmed/17717598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31093
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