Upregulation of NAD(P)H:Quinone Oxidoreductase By Radiation Potentiates the Effect of Bioreductive β-Lapachone on Cancer Cells

We found that β-lapachone (β-lap), a novel bioreductive drug, caused rapid apoptosis and clonogenic cell death in A549 human lung epithelial cancer cells in vitro in a dose-dependent manner. The clonogenic cell death caused by β-lap could be significantly inhibited by dicoumarol, an inhibitor of NAD...

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Bibliographic Details
Main Authors:	Choi, Eun K, Terai, Kaoru, Ji, In-Mi, Kook, Yeon H, Park, Kyung H, Oh, Eun T, Griffin, Robert J, Lim, Byung U, Kim, Jin-Seok, Lee, Doo S, Boothman, David A, Loren, Melissa, Song, Chang W, Park, Heon Joo
Format:	Artigo
Language:	Inglês
Published:	Neoplasia Press Inc. 2007
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC1950433/ https://ncbi.nlm.nih.gov/pubmed/17786182
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Upregulation of NAD(P)H:Quinone Oxidoreductase By Radiation Potentiates the Effect of Bioreductive β-Lapachone on Cancer Cells

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