Histone acetylation modifiers in the pathogenesis of malignant disease.

Chromatin structure is gaining increasing attention as a potential target in the treatment of cancer. Relaxation of the chromatin fiber facilitates transcription and is regulated by two competing enzymatic activities, histone acetyltransferases (HATs) and histone deacetylases (HDACs), which modify t...

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Bibliographic Details
Main Authors: Mahlknecht, U., Hoelzer, D.
Format: Artigo
Language:Inglês
Published: 2000
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1949974/
https://ncbi.nlm.nih.gov/pubmed/11055583
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