Deregulation of tumor angiogenesis and blockade of tumor growth in PPARβ-deficient mice

The peroxisome proliferator-activated receptor-β (PPARβ) has been implicated in tumorigenesis, but its precise role remains unclear. Here, we show that the growth of syngeneic Pparb wild-type tumors is impaired in Pparb(−/−) mice, concomitant with a diminished blood flow and an abundance of hyperpla...

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Detalhes bibliográficos
Main Authors: Müller-Brüsselbach, Sabine, Kömhoff, Martin, Rieck, Markus, Meissner, Wolfgang, Kaddatz, Kerstin, Adamkiewicz, Jürgen, Keil, Boris, Klose, Klaus J, Moll, Roland, Burdick, Andrew D, Peters, Jeffrey M, Müller, Rolf
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1949001/
https://ncbi.nlm.nih.gov/pubmed/17641685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601803
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